“What triggers puberty” is one of the 125 Big Questions posed in the 125th anniversary edition of Science magazine. We have recently revealed that the developmental programming of puberty onset is dependent on TBX3. We have also uncovered new rules for lineage progression, which operate through neuronal differentiation during the development of the hypothalamus. These results were published in Science Advances on Nov. 16.
The complexity and function of the nervous system relies on the generation of unparalleled neuronal diversity across molecular, morphological, functional and connectional features throughout developmental continuum. However, the strategies to generate neuronal diversity across different brain regions during development remain enigmatic.
Aging is a slow and progressive natural process that compromises the physiological functions of cells, tissues, organs and systems. The aging of the hypothalamic median eminence (ME), a structural gate linking neural and endocrine systems, may impair hormone release, energy homeostasis and central sensing of circulating molecules, leading to systemic and reproductive aging. However, the molecular and cellular features of hypothalamic aging remain largely unknown.
Hypothalamus maintains systemic homeostasis of animals and human beings by regulating endocrine, autonomous and behavioral functions. Heterogeneous populations of hypothalamic neurons orchestrate this functional versatility via the release of specific neurotransmitters and neuropeptides. Despite that recent studies have revealed the complex molecular diversity of hypothalamic peptidergic neurons, the developmental diversification and trajectory of these hypothalamic neurons remain unclear.
Hypothalamic tanycytes in median eminence(ME)are emerging as a crucial cell population that regulates endocrine output, energy balance and the diffusion of blood-born molecules.
The cerebral cortex of mammalian brain is organized into layers of specialized neuronal subtypes by orchestrated stem cell maintenance, expansion, fate commitment and differentiation.
This study was supported by the National Natural Science Foundation of China, the Chinese Academy of Sciences Pilot Project A, and the State Key Laboratory of Molecular Developmental Biology.
The structure of neural systems in the developing mammalian brain is dictated by tightly regulated cell generation and migration patterns. These include layered structures like the neocortex and cerebellum, and nuclear structures such as the thalamus and hypothalamus. Although the organization of layered structures has been well-studied, much less is known about how nuclear structures in the brain are formed.
We translated an essay “A natural history of human thinking” for Chinese version of Scientific American. The original author of this essay is Michael Tomasello from Harvard University. The Chinese version will be published in October 2018 in《环球科学》
A review article summarizing the role of chemerin in regulating metabolic disorders Metabolic syndrome is a global public health problem and predisposes individuals to obesity, diabetes and cardiovascular disease. Although the underlying mechanisms remain to be elucidated, accumulating evidence has uncovered a critical role of adipokines. Chemerin, encoded by the gene Rarres2, is a newly discovered adipokine involved in inflammation, adipogenesis, angiogenesis and energy metabolism.