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Publications
  • Lei, Y., Liang, X., Sun, Y., Yao, T., Gong, H., Chen, Z., Gao, Y., Wang, H., Wang, R., Huang, Y., Yang, T., Yu, M., Liu, L., Yi, C., Wu, Q.F., Kong, X., Xu, X., Liu, S.*, Zhang, Z.*, Liu, T.* (2024) Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus. Cell Metab. 36(2):438-453.e6.

  • Li, H., J, T., An, S., Xu, M., Guo, L., Ren, B., Shi, X., Wang, X., Yan, J., Yuan, J., Xu, X., Wu, Q.F., Luo, Q., Gong, H., Bian, W.*, Li, A.*, Yu, X.* (2024) Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns. Neuron. S0896-6273(23)01010-3.

  • Han, L., Liu, Z., Jing, Z., Liu, Y., Chang, H., Lei, J., Peng, Y., Wang, K., Xu, Y., Liu, W., Wu, Z., Li, Q., Shi, X., Zheng, M., Wang, H., Deng, J., Zhong, Y., Pan, H., Lin, J., Zhang, R., Chen, Y., Wu, J., Xu, M., Ren, B., Cheng, M., Yu, Q., Song, X., Wei, Y., Zhang, S., Dou, Y., Zhao, Y., Han, L., Zhu, Q., Xu, Y., Wang, S., Chen, H., Wang, D., Bai, Y., Liang,Y., Liu, Y., Chen, M., Xie, C., Bo, B., Li, M., Zhang, X., Ting, W., Chen, Z., Fang, J., Li, S., Jiang, Y., Tan, X., Zou, G., Xie, Y., Li, H., Tao, Q., Li, Y., Liu, J., Liu, Y., Hao, M., Wang, J., Wen, H., Liu, J., Yan, Y., Zhang, H., Sheng,Y., Han, M., Yu, S., Liao, X., Jiang, X., Wang, G., Liu, H., Wang, C., Feng, N., Liu, X., Ma, K., Xu, J., Han, T., Cao, H., Zheng, H., Chen, Y., Lu, H., Yu, Z., Zhang, J., Wang, B., Wang, Z., Xie, Q., Pan, S., Liu, C., Xu, C., Cui, L., Li, Y., Liu, S., Liao, S., Chen, A., Wu, Q.F., Wang, J., Liu, Z., Sun, Y., Mulder, J., Yang, H., Wang, Y.*, Li, C.*, Yao, J.*, Xu, X.*, Liu, L.*, Shen, Z.*, Wei, W.*, Sun, Y.* (2023)Spatially resolved molecular and cellular atlas of the mouse brain. bioRxiv. https://www.biorxiv.org/content/10.1101/2023.12.03.569501v1

  • Miao, Y., Fan, K., Peng, X., Li, S., Chen, J., Bai, R., Wei, Y., Deng, Y., Zhao, C.*, Wu, Q.F.*, Ge, M*., Gong, J.*, Wu, D.* (2023) Postoperative hypothalamic-pituitary dysfunction and long-term hormone replacement in patients with childhood-onset craniopharyngioma. Front Endocrinol.14:1241145.

  • Yao, Y., Chen, Z., Wu, Q.F., Lu, Y.*, Zhou X.*, Zhu, X.* (2023) Single-cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell-type-specific mechanisms. MedComm. 4(5):e372. 

  • Zhu, X., Meng, J., Han, C.,Wu, Q.F., Du, Y., Qi, J., Wei, L., Li, H., He, W., Zhang, K., Lu, Y.* (2023) CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety. Cell Dis. 9(1):94. doi: 10.1038/s41421-023-00588-2

  • Zhuang, Y., Li, Z., Xiong, S., Sun, C., Li, B., Wu, S.A., Lyu, J., Shi, X., Yang, L., Chen, Y., Bao, Z., Li, X., Sun, C., Chen, Y., Deng, H., Li, T., Wu, Q.F., Qi, L., Huang, Y., Yang, X., Lin, Y. (2023) Circadian clocks are modulated by compartmentalized oscillating translation. Cell. 186(15):3245-3260.e23. 

  • Sun, X., Chen, Z., Guo, X., Wang, J., Ge, M., Wong, S.Z.H., Wang, T., Li, S., Yao, M., Johnston, L.A., Wu, Q.F.* (2023) Stem cell competition driven by Axin2-p53 axis controls brain size during murine development. Dev Cell. DOI: https://doi.org/10.1016/j.devcel.2023. 03.016

  • Yao, Y., Wei, L., Chen, Z., Li, H., Qi, J., Wu, Q.F., Zhou, X., Lu, Y., Zhu, X.* (2023) Single-cell RNA sequencing: Inhibited Notch2 signalling underlying the increased lens fibre cells differentiation in high myopia. Cell Prolif. DOI:10.1111/cpr.13412

  • Shi, X., Zhuang, Y., Chen, Z., Xu, M., Kuang, J., Sun, X.L., Gao, L, Kuang, X., Zhang, H., Li, W., Wong, S.Z.H., Liu, C., Liu, L., Jiang, D., Pei, D., Lin, Y.*, Wu, Q.F.* (2022) Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset. Sci. Adv. 8, eabq2987.

  • Ge, M., Sheikhshahrokh, A., Shi, X., Zhang, Y.H., Xu, Z., Wu, Q.F.* (2022) A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity. Neurosci. Bull. 39, 645-658.

  • Hong, H., Zhao, Z., Huang, X., Guo, C., Zhao, H., Wang, G., Zhang, Y.P., Zhao, J.P., Shi, J., Wu, Q.F., Jiang, Y.H., Wang, Y., Li, L.M., Du, Z., Zhang, Y.Q.*, Xiong, Y.* (2022) Comparative proteome and cis-regulatory element analysis reveals specific molecular pathways conserved in dog and human brains. Mol Cell Proteomics. 21, 100261.

  • Wu, H.*, Fu, R., Zhang, Y.H., Liu, Z., Chen, Z., Xu, J., Tian, Y.*, Jin, W.*, Wong, S.Z.H.*, Wu, Q.F. (2022) Single-cell RNA sequencing unravels upregulation of immune cell crosstalk in relapsed pediatric ependymoma. Front Immunol. 13, 903246.

  • Chen, A., Liao, S., Cheng, M., Ma, K., Wu, L., Lai, Y., Qiu, X., Yang, J., Xu, J., Hao, S., Wang, X., Lu, H., Chen, X., Liu, X., Huang, X., Li, Z., Hong, Y., Jiang, Y., Peng, J., Liu, S., Shen, M., Liu, C., Li, Q., Yuan, Y., Wei X., Zheng, H., Feng, W., Wang Z., Liu, Y., Wang, Z., Yang, Y., Xiang, H., Han, L., Qin, B., Guo, P., Lai, G., Muñoz-Cánoves, P., Maxwell, P.H., Thiery, J.P., Wu, Q.F., Zhao, F., Chen, B., Li, M., Dai, X., Wang, S., Kuang, H., Hui, J., Wang, L., Fei, J.F., Wang, O., Wei, X., Lu, H., Wang, B., Liu, S., Gu, Y., Ni, M., Zhang, W., Mu, F., Yin, Y., Yang, H., Lisby, M., Cornall, R.J., Mulder, J., Uhlén, M., Esteban, M.A.*, Li, Y.*, Liu, L.*, Xu, X.*, Wang, J.* (2022) Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell. 185, 1777-1792.

  • Yun. H., Dumbell, R., Hanna, K., Bowen, J., Mclean, S.L., Kantamneni, S., Pors, K., Wu, Q.F., Helfer, G.* (2022) The chemerin-CMKLR1 axis is functionally important for central regulation of energy homeostasis. Front Physiol. 13, 897105.

  • Wu, H., Fu, R., Zhang, Y.H., Liu, Z., Chen, Z., Xu, J., Tian, Y., Jin, W., Wong, S.Z.H., Wu, Q.F. (2022) Single-cell RNA Sequencing of Pediatric Ependymoma Unravels Subclonal Heterogeneity Associated with Patient Survival. bioRxiv. https://www.biorxiv.org/content/10.1101/2022.02.26.482082v1.

  • Zhao, Z., Zhang, D., Yang, F., Xu, M., Zhao, S., Pan, T., Liu, C., Liu, Y., Wu, Q.F., Tu, Q., Zhou, P., Li, R., Kang, J., Zhu, L., Gao, F., Wang, Y.*, Xu Z.* (2022) Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing. Cell Res. 32, 425-436.

  • Yan, Y., Tian, M., Li, M., Zhou, G., Chen, Q., Xu, M., Hu, Y., Luo, W., Guo, X., Zhang, Cheng., Xie, H., Wu, Q.F., Xiong, W.*, Liu, S.*, Guan, J.* (2022) ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder. Neuron. 110, 1156-1172.

  • Chen, Z., Li, S., Xu, M., Liu, C., Ye, H., Wang, B., Wu, Q.F.* (2022) Single-cell Transcriptomic Profiling of the Hypothalamic Median Eminence during Aging. J Genet Genomics. 49, 523-536. (Cover story)

  • Wang, A., Wang, J., Tian, K., Huo, D., Ye, H., Li, S., Zhao, C., Zhang, B., Zheng, Y., Xu, L., Hua, X., Wang, K., Wu, Q.F., Wu, X., Zeng, T.*, Liu, Y.*, Zhou, Y.* (2021) An epigenetic circuit controls neurogenic programs during neocortex development. Development. 148 (22): dev199772.

  • Zhang, Y., Xu, M., Shi, X., Sun, X.L., Mu, W., Wu, H., Wang, J., Li, S., Su, P., Gong, L., He, M., Yao, M., Wu, Q.F.* (2021)  Cascade diversification directs generation of neuronal diversity in the hypothalamus. Cell Stem Cell. 28, 1483-1499.

  • Mu, W., Li, S., Xu, J., Guo, X., Wu, H., Chen, Z., Qiao, L., Helfer, G., Lu, F., Liu, C., Wu, Q.F.* (2021) Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. Nat Commun. 12, 2288.

  • Zhu, X.*, Du, Y., Li, D., Xu, J., Wu, Q.F., He, W., Zhang, K., Zhu, J., Guo, L., Qi, M., Liu, A., Qi, J., Wang, G., Meng, J., Yang, Z.*, Zhang, K.*, Lu, Y.* (2021) Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia. Nat Commun. 12, 2102.

  • Chang, Y., Jiang, Y., Li, C., Wang, Q., Zhang, F., Qin, C.F., Wu, Q.F., Li, J., Xu, Z.* (2021) Different Gene Networks are Disturbed by Zika Virus Infection in a Mouse Microcephaly Model. Genomics Proteomics Bioinformatics. 18, 737-748.

  • Wang J., Li T., Wang J., Xu Z., Meng W., Wu, Q.F.* (2020)  Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions. Cell Rep. 33, 108495.

  • Zhang, Y., Xu, M., Li, S., Wu, H., Shi, X., Guo, X., Mu, W., Gong, L., Yao, M., He, M., Wu, Q.F.* (2020) Cascade Diversification Directs the Generation of Neuronal Diversity in Hypothalamus. bioRxiv. 125054.

  • Berg, D.A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Rojas Ringeling F., Jain, R., Epstein, J.A., Wu, Q.F., Canzar, S., Ming, G.L.*, Song, H.*, and Bond, A.M.  (2019)   A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis. Cell. 18, 654-668. 

  • Tang, C., Wang, M., Wang, P., Wang, L., Wu, Q., and Guo, W.* (2019). Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. 101, 32-44.

  • Xu, M., Wang, J., Guo, X., Li, T., Kuang, X., Wu, Q.F.* (2018) Illumination of neural development by in vivo clonal analysis. Cell Regen. 12, 33-39.

  • Helfer, G., and Wu, Q.F.* (2018). Chemerin: a multifaceted adipokine involved in metabolic disorders. J Endocrinol. 238, R79-R94.

  • Wong, S.Z.H., Scott, E.P., Mu, W., Guo, X., Borgenheimer, E., Freeman, M., Ming, G.L., Wu, Q.F.*, Song, H.*, and Nakagawa, Y.* (2018). In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis. PLoS Biol. 16, e2005211.

  • Wei, D., Gao, N., Li, L., Zhu, J.X., Diao, L., Huang, J., Han, Q.J., Wang, S., Xue, H., Wang, Q., Wu, Q.F., Zhang, X., and Bao, L.* (2017). alpha-Tubulin acetylation restricts axon overbranching by dampening microtubule plus-end dynamics in neurons. Cereb Cortex. 28, 3332-3346.

  • Yoon, K.J., Song, G., Qian, X., Pan, J., Xu, D., Rho, H.S., Kim, N.S., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E.M., Huang, W.K., Ringeling, F.R., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C.F., Wu, Q., Christian, K.M., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., and Ming, G.L.* (2017). Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins. Cell Stem Cell. 21, 349-358.

  • Oh, Y., Zhang, F., Wang, Y., Lee, E.M., Choi, I.Y., Lim, H., Mirakhori, F., Li, R., Huang, L., Xu, T., Wu, H., Li, C., Qin, C.F., Wen, Z., Wu, Q.F., Tang, H.*, Xu, Z.*, Jin, P.*, Song, H., Ming, G.L.*, Lee, G. (2017). Zika virus directly infects peripheral neurons and induces cell death. Nat Neurosci. 20, 1209-1212.

  • Yang, L., Dong, F., Yang, Q., Yang, P.F., Wu, R., Wu, Q.F., Wu, D., Li, C.L., Zhong, Y.Q., Lu, Y.J., Cheng X, Xu FQ, Chen L, Bao L, Zhang X.* (2017). FGF13 selectively regulates heat nociception by interacting with Nav1.7. Neuron. 93, 806-821.

  • Liu, H., Wu, Q.F., Li, J.Y., Liu, X.J., Li, K.C., Zhong, Y.Q., Wu, D., Wang, Q., Lu, Y.J., Bao, L., Zhang X.* (2015). Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles. J Mol Cell Biol. 7, 466-475.

  • Zhang, X.*, Bao, L., Yang, L., Wu, Q., and Li, S. (2012). Roles of intracellular fibroblast growth factors in neural development and functions. Sci China Life Sci. 55, 1038-1044.

  • Wu, Q.F., Yang, L., Li, S., Wang, Q., Yuan, X.B., Gao, X., Bao, L., and Zhang, X.* (2012). Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 149, 1549-1564.

  • Liu, X.J., Zhang, F.X., Liu, H., Li, K.C., Lu, Y.J., Wu, Q.F., Li, J.Y., Wang, B., Wang, Q., Lin, L.B., Zhong, Y.Q., Xiao, H.S., Bao, L., and Zhang, X.* (2012). Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain. 135, 391-403.